Health test results
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There is no substitute to visiting your Vet - he has the knowledge and experience and can see/feel/smell your dog and advise accordingly. Please apply your own judgement and common sense to any advice given. What works for one dog might not work for another. If you are in any doubt please visit your Vet! General Forum Rules
There is no substitute to visiting your Vet - he has the knowledge and experience and can see/feel/smell your dog and advise accordingly. Please apply your own judgement and common sense to any advice given. What works for one dog might not work for another. If you are in any doubt please visit your Vet! General Forum Rules
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Spaniel Jim
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- Posts: 568
- Joined: Mon Aug 16, 2010 8:42 am
- Dogs: Ria, Berry,Max,Fay, Moss, Murphy, Finn
- Location: Cornwall
Re: Health test results
right, she wouldn't be affected though would that be right?
Angarrick gundogs
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vicky payne
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- Posts: 2500
- Joined: Sat May 14, 2011 5:45 pm
Re: Health test results
No, she won't be affected. If she was though you'd know with fuco as she'd be dead!
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Spaniel Jim
- Member
- Posts: 568
- Joined: Mon Aug 16, 2010 8:42 am
- Dogs: Ria, Berry,Max,Fay, Moss, Murphy, Finn
- Location: Cornwall
Re: Health test results
Still very much alive this morning:-D . Its the pra thing that that people talk about.im very novice when it comes to all this sort of think.as already shown!
Angarrick gundogs
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vicky payne
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- Joined: Sat May 14, 2011 5:45 pm
Re: Health test results
I'll explain genetics later if you like!
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vicky payne
- Member
- Posts: 2500
- Joined: Sat May 14, 2011 5:45 pm
Re: Health test results
Ok....so most of the diseases we have DNA tests for in dogs are called 'simple recessive mutations'. This means just one faulty gene is causes the problem. Other problems like hip dysplasia are probably mutifactorial with many genes involved. You have two genes for everything in your body; one from your mum and one from your dad. The 'recessive' word means that one bad copy can't cause the disease. So any any simple recessive condition a dog can be described genetically like this;
RR = two normal copies of the gene (called unaffected)
Rr = one normal and one defective copy of the gene (called carrier)
rr = two defective copies of the gene (called affected)
Of these only rr will show any clinical signs; in some diseases like fucosidosis this cause a nasty disease and death in a young dog. In others like cord1 PRA it will cause blindness, but this may happen later in life which limits the usefullness of the KV/BVA examination.
When it comes to breeding
RR x RR will only produce RR puppies.
rr x rr will only produce rr puppies
When things get interesting is when you mate Rr; a carrier dog
Rr x RR can produce RR and Rr; neither can get ill but you can produce Rr the carriers.
Rr x Rr can produce RR and Rr but also rr so should be avoided.
As you can see a 'clear' dog 'RR' could have either RRxRR, RrxRr or Rr xRR parents.
Does that help?!
RR = two normal copies of the gene (called unaffected)
Rr = one normal and one defective copy of the gene (called carrier)
rr = two defective copies of the gene (called affected)
Of these only rr will show any clinical signs; in some diseases like fucosidosis this cause a nasty disease and death in a young dog. In others like cord1 PRA it will cause blindness, but this may happen later in life which limits the usefullness of the KV/BVA examination.
When it comes to breeding
RR x RR will only produce RR puppies.
rr x rr will only produce rr puppies
When things get interesting is when you mate Rr; a carrier dog
Rr x RR can produce RR and Rr; neither can get ill but you can produce Rr the carriers.
Rr x Rr can produce RR and Rr but also rr so should be avoided.
As you can see a 'clear' dog 'RR' could have either RRxRR, RrxRr or Rr xRR parents.
Does that help?!